FTF225 - TISSUE ENGINEERING II
Course higher education credits 7.5
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Portrait of Julie Gold, instrumental to this research. The presskit photo has been
lovingly transcoded and the resultant image manipulated.
The artist hopes in this was to recapitulate ontology with
a phylogeny appropriately
synthetic. Post-processing by a female faust, dated with this post. |
Course is normally given LP4Graduate schoolDepartment Applied Physics Contact information
julie.gold@chalmers.seCourse description
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Aim
The aim of this course is to provide students experience in working in groups on an experimental research project on a topic of relevance to tissue engineering. The project work begins in the preceeding course KPO065 Tissue engineering I and involves the design, execution and analysis of experiments and their results. An additional aim of the course is to provide specific knowledge on scientific and technical aspects of growing tissues and organs, as well as broader understanding of the challenges of producing , storing, delivering and using tissue engineered products, and their ethical and regulatory issues.
Learning outcome (after completion of this course, the student should be able to)
Present and defend methods used and results obtained from laboratory experiments of growing tissue engineered constructs.
Define what is a stem cell, the different types of stem cells, and describe various approaches to derive stem cell lines.
Have a basic understanding of stem cell proliferation and differentiation processes.
Describe important tools for characterizing cell and tissue properties, and which properties are of interest to charactize.
Cite applications of gene transfer in tissue engineering. Describe several viral and non-viral approaches of gene transfer.
Describe a general first approach for bioreactor design considerations and scale-up of cell culture. Understand the importance, and dimensions, of the cellularity and geometry of the tissue microenvironment.
Describe methods to modify biomaterial surfaces on sub-cellular, cellular and supracellular length scales.
Understand the processes of wound healing, angiogenesis and the immune response in the case of implantation/transplantation of tissue engineered constructs. Be familiar with approaches to control immune rejection and to achieve immunoisolation of tissue engineered constructs.
Be familiar with methods to preserve tissue engineered products.
Discuss key safety, ethical and regulatory issues around tissue engineered products.
Critically evaluate scientific publications in the tissue engineering field.
Content This course is the continuation course to Tissue Engineering I and covers the following topics: Clinical Implementation of tissue engineering: Host integration Cell and tissue properties Characterization of growing tissues and cells, Gene therapy and drug delivery Stem cells Tailoring of biomaterials for scaffold optimizationj Producing TE products Ethical issues with TE Regulatory issues of TE products
Organization The course will consist of lectures, article review sessions and laboratory work. Laboratory work will be carried out within the group projects, and will be dependent on the specific project topic. The students will interact with scientists developing various tissues such as cartilage, bone, neural tissues and blood vessels.
Literature Bhatia and Palsson, Tissue engineering, 2004. Handouts of lecture notes and scientific articles.
Examination Grades for the course will be based on article review sessions, the group project oral and written presentations, and an individual grade from group members.
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